Benzoxazole-6-carboxylic Acid

Benzoxazole-6-carboxylic Acid - Names and Identifiers

Name	benzo[d]oxazole-6-carboxylic acid
Synonyms	6-Benzoxazolecarboxylic acid Benzoxazole-6-carboxylic Acid benzo[d]oxazole-6-carboxylic acid 1,3-Benzoxazole-6-carboxylic acid
CAS	154235-77-5

Benzoxazole-6-carboxylic Acid - Physico-chemical Properties

Molecular Formula	C8H5NO3
Molar Mass	163.13
Density	1.455±0.06 g/cm3(Predicted)
Melting Point	280-290 °C (sublm)(Press: 16 Torr)
Boling Point	350.1±15.0 °C(Predicted)
pKa	3.60±0.30(Predicted)
Storage Condition	2-8°C

Benzoxazole-6-carboxylic Acid - Reference Information

Introduction

1, 3-benzoxazol-6-carboxylic acid is an organic intermediate, It can be prepared by the reaction of 4-amino-3-hydroxybenzoic acid and trimethyl orthoformate.

preparation method

the mixture of 4-amino-3-hydroxybenzoic acid (250mg,1.63mmol) and trimethyl orthoformate (500 μL,
4.57mmol) was heated in an oil bath at 100 ℃ for 2 hours. The mixture was cooled to room temperature and diluted with
MeOH, and the resulting solution was filtered through the sirite diatomite filler, and the filtrate was vacuum concentrated to obtain 1, 3-benzoxazol-6-carboxylic acid brown solid (2337 mg,89%):1H
NMR(DMSO-d6)δ13.2,8.9,8.3,8.0,7.9.

Last Update：2024-04-09 21:21:28